Raj and Howard are determined to find out what Sheldon is doing for twenty minutes every day in a storage room in the Caltech basement. Meanwhile, Howard prepares to finally move out of mother's house to live with Bernadette. Problems arise when Amy and Wil appear to dislike each other and Sheldon is torn on whose side to take. Sheldon tapes another episode of " Fun With Flags", only this time, the episode will focus on Star Trek flags so he brings his friend Wil Wheaton as a guest. Meanwhile, Penny considers telling Leonard about the fact that she is going back to school by taking a history class at a community college. Sheldon is excited when Stephen Hawking accepts his invitation to play a popular online game with him. Penny decides to learn more about Leonard's job, and Sheldon and Amy are at odds on what to wear to the Halloween party. Bernadette has to deal with an annoying Howard who cannot stop talking about space. Stuart wants to organize a Halloween party at his comic book store so Raj steps up to become the party planner. Meanwhile, Sheldon, Leonard, Penny, and Amy take part in a girls versus guys competition. Bernadette is also too sick to comfort him. Howard finally returns to Earth, only to discover that changes have happened that leave him dejected, such as Stuart replacing him as Raj's best friend and mother having an affair with his dentist. Meanwhile, Howard informs Bernadette that he needs to stay in space for an additional 7-10 days. Amy gets jealous and asks Penny to spy on her at Caltech, only to find out that Alex is flirting with Leonard instead. Sheldon hires an attractive grad student named Alex Jensen to help him. Meanwhile, Howard gets bullied by his fellow astronauts. Stuart becomes Raj's new hang-out buddy to fill the gap left by Howard, and gets accepted into the social group by Sheldon. Sheldon tries to get Penny to stay in the relationship. Penny tries to figure out her feelings for Leonard with the help of Bernadette and Amy. Meanwhile, a still-in-space Howard gets in a dilemma with his wife and mother over where he will choose to live once he returns to Earth. As a result, Raj interrupts Leonard and Penny's, only to get kicked out when he tells Penny to acknowledge her feelings for Leonard, prompting him to go to the comic book store instead. Sheldon, Amy, Leonard, and Penny all have dates, but Sheldon invites Raj to his date with Amy, upsetting Amy. Ian Scott Rudolph as Captain Sweatpants (2/24).Carol Ann Susi as Debbie Wolowitz (4/24).Melissa Rauch as Bernadette Rostenkowski-Wolowitz (23/24).Mayim Bialik as Amy Farrah Fowler (22/24).Kunal Nayyar as Rajesh Koothrappali (24/24).Simon Helberg as Howard Wolowitz (24/24).Johnny Galecki as Leonard Hofstadter (24/24).
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The Kaplan-Meier method for estimating survival functions and the Cox proportional hazards model for estimating the effects of covariates on the hazard of the occurrence of the event are commonly used statistical methods for the analysis of survival data. Others refer to such data as time-to-event data or event history data. We use the term survival data to refer to data in which the outcome variable denotes the time to the occurrence of the event of interest. Less common examples include time to shock or appropriate therapy in patients undergoing implantable cardiac defibrillator implantation or time to heart transplant in patients on a transplant waiting list. Common examples include time to death attributable to any cause, time to cause-specific death (eg, death attributable to cardiovascular causes), and time to the first of any major adverse cardiac event (MACE eg, cardiovascular death or acute myocardial infarction). Statistical software code in both R and SAS is provided.Ĭardiovascular research often focuses on outcomes that are defined as the time to the occurrence of an outcome of interest. We illustrate the application of these methods by examining cause-specific mortality in patients hospitalized with heart failure. The former family of models may be better suited for addressing etiologic questions, whereas the latter model may be better suited for estimating a patient’s clinical prognosis. The latter allows one to estimate the effect of covariates on the absolute risk of the outcome over time. The former allows one to estimate the effect of the covariates on the rate of occurrence of the outcome in those subjects who are currently event free. When fitting regression models in the presence of competing risks, researchers can choose from 2 different families of models: modeling the effect of covariates on the cause-specific hazard of the outcome or modeling the effect of covariates on the cumulative incidence function. The use of the Kaplan-Meier survival function results in estimates of incidence that are biased upward, regardless of whether the competing events are independent of one another. When estimating the crude incidence of outcomes, analysts should use the cumulative incidence function, rather than the complement of the Kaplan-Meier survival function. In a study examining time to death attributable to cardiovascular causes, death attributable to noncardiovascular causes is a competing risk. A competing risk is an event whose occurrence precludes the occurrence of the primary event of interest. 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